A recent study reveals that patients who come off popular GLP-1 drugs like Mounjaro or Wegovy can put back on lost weight much more quickly than those who end traditional lifestyle programs.
Research printed in a prominent health publication demonstrates that while overweight individuals frequently drop about a fifth of their body weight while undergoing treatment, the weight is regained at an average rate of nearly a kilo each month after stopping.
"Users buying these drugs must be informed of the danger of fast weight regain when the therapy ends," stated expert Dr. Susan Jebb.
That rate of recovery suggests a return to pre-treatment mass in about a year and a half.
Comparing Therapies
The research, which reviewed 37 of trials involving over 9,000 of patients, contrasted the effects of the injectable medications with other pills.
Researchers point out that individuals who shed pounds through diet and exercise generally see a more gradual weight regain—approximately 0.1 kg a month—once they finish.
Explaining the Quick Regain
Nutrition scientists suggest the mechanism of the jabs is key to understanding the heightened rebound.
GLP-1 drugs mimic a natural hormone called GLP-1, which controls hunger.
"Sustained high doses of the hormone levels far above than the body's typical production may cause the body to produce less of its endogenous hormone, and may also lessen responsiveness to its effects," said Dr. Adam Collins, a nutrition specialist.
"Stopping of this medication results in appetite is uncontrolled, making overeating much more probable."
A Chronic Condition?
The NHS recommend the jabs for people with obesity-related health risks, accompanied by recommended lifestyle changes.
A number of clinicians say that, given the significant potential of weight regain, the therapy might need to be ongoing.
This perspective is echoed by pharmaceutical companies, who note that the results "underscore the chronic character of excess weight," comparing it to managing diseases like diabetes.
Patient Accounts
Individuals who have stopped the medication describe a powerful resurgence of hunger.
"I experienced a trigger flipping and you're instantly ravenous," described an individual.
The struggle is compounded if individuals have not developed sustainable dietary or behavioural changes during treatment.
Widespread Interest
Recent estimates show that a significant number of adults in the UK have tried these injections in the last 12 months, with demand remaining high.
- Use is greater among females compared to men.
- The middle-aged age group shows the highest usage rates.
- Many obtain the medications through private prescriptions rather than the NHS.
Finally, researchers stress that while the jabs are powerful agents for weight loss, they are not a permanent cure and lasting health benefits hinges on combined behavioural changes.
